Metformin – its potential anti-cancer and anti-aging effects | Zendy

Monika Podhorecka | Zendy; Blanca Gil Ibáñez | Zendy; Anna Dmoszyńska | Zendy

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Metformin – its potential anti-cancer and anti-aging effects

Author(s) -

Monika Podhorecka,

Blanca Gil Ibáñez,

Anna Dmoszyńska

Publication year - 2017

Publication title -

postępy higieny i medycyny doświadczalnej

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 34

eISSN - 1732-2693

pISSN - 0032-5449

DOI - 10.5604/01.3001.0010.3801

Subject(s) - metformin , ampk , protein kinase a , adenosine monophosphate , adenosine , diabetes mellitus , medicine , amp activated protein kinase , metabolic syndrome , cancer , endocrinology , pharmacology , kinase , biology , microbiology and biotechnology

The generally accepted mechanism of metformin's effect is stimulation of adenosine monophosphate (AMP)-activated protein kinase (AMPK). AMPK is directly activated by an increase in AMP:ATP ratio in metabolic stress conditions including hypoxia and glucose deprivation. Lately, many novel pathways, besides AMPK induction, have been revealed, which can explain some of metformin's beneficial effects. It may help to identify new targets for treatment of diabetes and metabolic syndrome. Moreover, metformin is now attracting the attention of researchers in fields other than diabetes, as it has been shown to have anti-cancer, immunoregulatory and anti-aging effects. The aim of this review is to describe the potential anti-cancer and anti-aging properties of metformin and discuss the possible underlying mechanisms.

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