Influence of oxygen concentration on T cell proliferation and susceptibility to apoptosis in healthy men and women | Zendy

Agnieszka Waskowska | Zendy; Katarzyna A. Lisowska | Zendy; Agnieszka Daca | Zendy; Izabella Henc | Zendy; Fredrik Brandberg | Zendy; Paula Mazurek | Zendy; Edyta Brzustewicz | Zendy; Jacek M. Witkowski | Zendy; Ewa Bryl | Zendy

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Influence of oxygen concentration on T cell proliferation and susceptibility to apoptosis in healthy men and women

Author(s) -

Agnieszka Waskowska,

Katarzyna A. Lisowska,

Agnieszka Daca,

Izabella Henc,

Fredrik Brandberg,

Paula Mazurek,

Edyta Brzustewicz,

Jacek M. Witkowski,

Ewa Bryl

Publication year - 2017

Publication title -

folia histochemica et cytobiologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.384

H-Index - 40

eISSN - 1897-5631

pISSN - 0239-8508

DOI - 10.5603/fhc.a2017.0006

Subject(s) - cd28 , apoptosis , cd8 , t cell , cell cycle , cd3 , immunology , biology , t lymphocyte , cell growth , microbiology and biotechnology , chemistry , immune system , andrology , medicine , biochemistry

Much of what we know about the functioning of human T lymphocytes is based on the experiments carried out in atmospheric oxygen (O₂) concentrations, which are significantly higher than those maintained in blood. Interestingly, the gender differences in the activity of T cells and their susceptibility to apoptosis under different O₂ conditions have not yet been described. The aim of the study was to compare two main markers of lymphocyte function: proliferation capacity and ability to produce cytokines as well as their susceptibility to apoptosis under two different O₂ concentrations, between men and women.

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