Caspase-3 as an important factor in the early cytotoxic effect of nickel on oral mucosa cells in patients treated orthodontically | Zendy

Piotr Buczko | Zendy; Izabela Szarmach | Zendy; Monika Grycz | Zendy; Irena Kasacka | Zendy

Open Access

Caspase-3 as an important factor in the early cytotoxic effect of nickel on oral mucosa cells in patients treated orthodontically

Author(s) -

Piotr Buczko,

Izabela Szarmach,

Monika Grycz,

Irena Kasacka

Publication year - 2017

Publication title -

folia histochemica et cytobiologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.384

H-Index - 40

eISSN - 1897-5631

pISSN - 0239-8508

DOI - 10.5603/fhc.a2017.0004

Subject(s) - oral mucosa , saliva , apoptosis , oral cavity , caspase 3 , caspase , cytotoxic t cell , medicine , chemistry , dentistry , pathology , in vitro , programmed cell death , biochemistry

The effect of fixed orthodontic appliances on biochemical changes in saliva and pathophysiological status of the oral cavity is not clear. Recent data showed that nickel (Ni) released from orthodontic appliances can decrease cellular viability, induce DNA damage and apoptosis in oral mucosa cells. Since the mechanism of these Ni effects is unknown, the aim of our study was to analyze the expression of caspase-3 in epithelial cells of oral mucosa in healthy individuals treated orthodontically.

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