Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-κB signaling in LPS-induced PC3 cells | Zendy

Deniz Ogut | Zendy; Buket Reel | Zendy; Ceren Gönen Korkmaz | Zendy; Mehmet Zuhuri Arun | Zendy; Serap Çilaker Mıçılı | Zendy; Bekir Uğur Ergür | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-κB signaling in LPS-induced PC3 cells

Author(s) -

Deniz Ogut,

Buket Reel,

Ceren Gönen Korkmaz,

Mehmet Zuhuri Arun,

Serap Çilaker Mıçılı,

Bekir Uğur Ergür

Publication year - 2016

Publication title -

folia histochemica et cytobiologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.384

H-Index - 40

eISSN - 1897-5631

pISSN - 0239-8508

DOI - 10.5603/fhc.a2016.0022

Subject(s) - matrix metalloproteinase , doxycycline , angiogenesis , chemistry , cell growth , cancer research , iκbα , extracellular matrix , signal transduction , lipopolysaccharide , nf κb , microbiology and biotechnology , biology , immunology , biochemistry , antibiotics

Matrix metalloproteinase enzymes (MMPs) play important role in inflammation, malignant cell proliferation, invasion and angiogenesis by mediating extracellular matrix degradation. Doxycycline, a synthetic tetracycline, behaves as a MMP inhibitor at a subantimicrobial dose and inhibits tumor cell proliferation, invasion and angiogenesis. The aberrant activity of nuclear factor kappa B (NF-κB) causes activation of MMPs and thereby proliferation and invasion of cancer cells. The aim of this study was to investigate the effects of doxycycline on the expression of MMPs in lipopolysaccharide (LPS)-induced PC3 human prostate cancer cells and the possible role of NF-κB signaling.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research