Influence of IGF1, TGFβ1, bFGF and G-CSF/M-CSF on the mRNA levels of selected matrix proteins, cytokines, metalloproteinase 3 and TIMP1 in rat synovial membrane cells | Zendy

Anna OsieckaIwan | Zendy; S Moskalewski | Zendy; Anna Hyc | Zendy

Open Access

Influence of IGF1, TGFβ1, bFGF and G-CSF/M-CSF on the mRNA levels of selected matrix proteins, cytokines, metalloproteinase 3 and TIMP1 in rat synovial membrane cells

Author(s) -

Anna OsieckaIwan,

S Moskalewski,

Anna Hyc

Publication year - 2016

Publication title -

folia histochemica et cytobiologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.384

H-Index - 40

eISSN - 1897-5631

pISSN - 0239-8508

DOI - 10.5603/fhc.a2016.0019

Subject(s) - timp1 , matrix metalloproteinase , messenger rna , metalloproteinase , transforming growth factor , chemistry , synovial membrane , matrix (chemical analysis) , medicine , endocrinology , inflammation , microbiology and biotechnology , gene expression , biology , biochemistry , gene , chromatography

We have previously observed that rat synovial membranes incubated in medium containing cartilage interstitial fluid (CIF) responded by changes in the expression of hyaluronan synthases (HAS1 and HAS2), collagen type I, versican, aggrecan, lubricin, matrix metalloproteinases 2 and 3 (MMP2 and MMP3), tissue inhibitors of metalloproteinases (TIMP1, 2 and 3), transforming growth factor β1 (TGFβ1), tumor necrosis factor (TNF), interleukin (IL) 1β and IL-6. The aim of the study was to evaluate the influence of particular cytokines found in CIF on the gene expression of extracellular matrix (ECM) proteins in synovial membrane cells.

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