Effects of rosmarinic acid on cognitive and biochemical alterations in ovariectomized rats treated with D-galactose | Zendy

Deniz Kantar | Zendy; Nihal Öztürk | Zendy; Hakan Er | Zendy; Mutay Aslan | Zendy; Necdet Demır | Zendy; Narin Derin | Zendy; Ayşel Ağar | Zendy; Piraye Yargıçoğlu | Zendy

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Effects of rosmarinic acid on cognitive and biochemical alterations in ovariectomized rats treated with D-galactose

Author(s) -

Deniz Kantar,

Nihal Öztürk,

Hakan Er,

Mutay Aslan,

Necdet Demır,

Narin Derin,

Ayşel Ağar,

Piraye Yargıçoğlu

Publication year - 2015

Publication title -

folia histochemica et cytobiologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.384

H-Index - 40

eISSN - 1897-5631

pISSN - 0239-8508

DOI - 10.5603/fhc.a2015.0034

Subject(s) - ovariectomized rat , rosmarinic acid , medicine , endocrinology , open field , thiobarbituric acid , galactose , morris water navigation task , lipid peroxidation , chemistry , oxidative stress , hippocampus , antioxidant , biochemistry , estrogen

Animal models designed to mimic certain features of Alzheimer's disease (AD) can help us to increase our understanding of the underlying mechanisms of disease. Previous studies have revealed that long-term D-galactose injection combined with ovariectomy results in pathophysiologic alterations associated with AD. Thus, the aim of the present study was to investigate the effects of rosmarinic acid (RA) administration on pathological changes associated with ovariectomy and D-galactose injection, which serve as a two-insult model for AD.

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