CD163 and its role in inflammation | Zendy

Krzysztof Kowal | Zendy; Richard F. Silver | Zendy; Emila Sławińska | Zendy; M Bielecki | Zendy; L Chyczewski | Zendy; Otylia KowalBielecka | Zendy

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CD163 and its role in inflammation

Author(s) -

Krzysztof Kowal,

Richard F. Silver,

Emila Sławińska,

M Bielecki,

L Chyczewski,

Otylia KowalBielecka

Publication year - 2011

Publication title -

folia histochemica et cytobiologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.384

H-Index - 40

eISSN - 1897-5631

pISSN - 0239-8508

DOI - 10.5603/fhc.2011.0052

Subject(s) - cd163 , inflammation , macrophage , immunology , monocyte , peripheral blood mononuclear cell , population , biology , inflammatory response , medicine , in vitro , biochemistry , environmental health

Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The expression of CD163 is strongly induced by anti-inflammatory mediators such as glucocorticoids and interleukin-10, while being inhibited by pro-inflammatory mediators such as interferon-gamma. CD163-expressing mononuclear phagocytes, as well as soluble CD163, may both take part in downregulating an inflammatory response. It seems, therefore, that CD163 may be an interesting target for therapeutic modulation of the inflammatory response.

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