Use of implantable cardioverter-defibrillators for primary prevention in older patients: A systematic literature review and meta-analysis | Zendy

Melissa H. Kong | Zendy; Sana M. AlKhatib | Zendy; Gillian D Sanders | Zendy; Vic Hasselblad | Zendy; Eric D. Peterson | Zendy

Open Access

Use of implantable cardioverter-defibrillators for primary prevention in older patients: A systematic literature review and meta-analysis

Author(s) -

Melissa H. Kong,

Sana M. AlKhatib,

Gillian D Sanders,

Vic Hasselblad,

Eric D. Peterson

Publication year - 2011

Publication title -

cardiology journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.573

H-Index - 33

eISSN - 1897-5593

pISSN - 1898-018X

DOI - 10.5603/cj.2011.0005

Subject(s) - medicine , meta analysis , randomized controlled trial , clinical endpoint , implantable cardioverter defibrillator , observational study , sudden cardiac death , medline , primary prevention , disease , political science , law

Randomized clinical trials (RCTs) have demonstrated the efficacy of implantable cardioverter-defibrillators (ICDs) in reducing sudden cardiac death (SCD) in specific patient populations. However, patients ≥ 65 years were under-represented in these trials and the overall benefit of ICDs may be diminished in older patients due to competing risks for death. We evaluate the published data on ICD efficacy at reducing all-cause mortality in patients ≥ 65 years and in patients ≥ 75 years.

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