Increased apoptotic activity on inflammatory human placentas in spontaneous abortions during the first and second trimester of gestation: a histochemical and immunohistochemical study | Zendy

Alexandros Papalambros | Zendy; Elias Papadopoulos | Zendy; Ιορδάνα Γραμματικοπούλου | Zendy; Olga Pagonopoulou | Zendy; Petros Ypsilantis | Zendy; Μaria Κoffa | Zendy; Εkaterini Chatzaki | Zendy; Maria Lambropoulou | Zendy; Theodora-Eleftheria Deftereou | Zendy; Emmanouil Kontomanolis | Zendy; Νικόλας Παπαδόπουλος | Zendy

Open Access

Increased apoptotic activity on inflammatory human placentas in spontaneous abortions during the first and second trimester of gestation: a histochemical and immunohistochemical study

Author(s) -

Alexandros Papalambros,

Elias Papadopoulos,

Ιορδάνα Γραμματικοπούλου,

Olga Pagonopoulou,

Petros Ypsilantis,

Μaria Κoffa,

Εkaterini Chatzaki,

Maria Lambropoulou,

Theodora-Eleftheria Deftereou,

Emmanouil Kontomanolis,

Νικόλας Παπαδόπουλος

Publication year - 2012

Publication title -

doaj (doaj: directory of open access journals)

Language(s) - English

DOI - 10.5603/18706

Subject(s) - immunohistochemistry , gestation , apoptosis , first trimester , andrology , obstetrics , abortion , medicine , pregnancy , gynecology , biology , pathology , genetics

The aim of this study was to investigate the role of apoptotic markers on inflammatory human placentas from spontaneous abortions during the first and second trimester of gestation and compare them to those without inflammation. Paraffin-embedded specimens from 76 placentas were investigated by conventional histology and immunohistochemistry using monoclonal antibodies against M30, Caspase 3, Caspase 8 and Caspase 9, as well as the terminal deoxynucleotidyl tranferase-mediated deoxyuridine triphosphate nick end labeling method. A higher prevalence of expression of apoptotic markers (94.4%) was observed in placentas associated with chorioamnionitis in comparison with those without inflammation. Our observations confirm that apoptosis is strikingly prevalent in placentas diagnosed with histologic chorioamnionitis, while the inflammation induces cell death

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