Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives | Zendy

Peng Zhan | Zendy

Open Access

Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives

Author(s) -

Peng Zhan

Publication year - 2011

Publication title -

drug discoveries and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.404

H-Index - 23

eISSN - 1881-784X

pISSN - 1881-7831

DOI - 10.5582/ddt.2011.v5.6.279

Subject(s) - chemistry , mass spectrum , halide , human immunodeficiency virus (hiv) , ring (chemistry) , alkyl , medicinal chemistry , stereochemistry , organic chemistry , ion , virology , biology

A series of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazines (PTDs) was prepared starting from a ring of pyrazolo[4,5-e][1,2,4]thiadiazine nuclei with two different alkyl halides obtained by a facile one-pot reaction. The structures of all synthesized compounds were confirmed by 1H- and 13C-NMR, infrared spectra (IR), and mass spectra (MS) spectroscopic analysis. Anti-HIV activity was evaluated and none of the compounds were found to inhibit HIV replication in human T-lymphocyte (MT-4) cell culture.

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