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Background and objectives Laparoscopic surgeries are associated with an appreciably high rate of post operative nausea and vomiting (PONV). This study was designed to compare the effectiveness of Ondansetron with that of Granisetron for prevention of PONV after laparoscopic surgery and their effect on clinical recovery and recovery time.Methods This is a randomized prospective study of 60 adult patients of both sexes received either Ondansetron 4mg or Granisetron 2mg intravenously at the end of surgery. Perioperative anaesthetic care was standardized in all patients. Patients were then observed 24 hours after administration of the study drug.Results A complete response (defined as no PONV and no need for another rescue antiemetic) was achieved in 75% of the patients given ondansetron and 86% of the patients given granisetron with (p<.05%). No significant difference observed in the recovery time from anesthesia between the two drugs and slight differences in the adverse events were observed between the two groups.Conclusion This study concludes that the prophylactic intravenous administration of Granisetron is more effective drug than ondansetron for controlling postoperative nausea and vomiting with fewer incidences of side effects.

A Comparative Study Of Ondansetron And Granisetron For Prevention Of Nausea And Vomiting Following Laparoscopic Surgeries