Evaluation of Anti-diarrhea activity of Rhizophora <italic>mucronata</italic> bark extracts

Rhizophora mucronata is seen along the tropical coastal line is associated with many medicinal activities. The purpose of present study is to investigate the anti-diarrhea activity of Rhizophora mucronata bark extracts as traditional used by people of India. The chloroform, ethyl acetate methanol and water extracts were subjected for antidiarrhea activity in castor oil induced and gastrointestinal motility test in albino mice and effect on spasmogen induced contractility in isolated guinea pig ileum. The phytochemical analysis was carried. The bark extracts showed inhibition of castor oil induced diarrhea and very significant percentage inhibition of charcoal meal in mice. The bark extracts did not inhibit the acetylcholine and histamine induced contraction of isolated guinea pig ileum up to 10 mg/ml concentrations. The study supports the anti diarrhea activity of Rhizophora mucronata bark, as evident from the castor oil induced and gastrointestinal motility and indicating a different mechanism of action.