The Effects of Kisspeptin System on Ewe Reproduction

Kiss1 geni, kiss1 reseptoru ve kisspeptin peptid sistemi reproduktif fonksiyonlarin duzenlenmesinde onemli rol oynamaktadir. Kiss1 gen urunu olan 145 amino asit yapisina sahip prekursor proteini aktif kisspeptin formlarina donusmektedir. Kisspeptin sisteminin gonodal steroitlerin negatif ve pozitif feedback mekanizmasinda onemli rolleri vardir. Hipotalamus’un arkuat ve preoptik bolgelerindeki toplam kisspeptin hucre sayisi farkli olup, bu hucre sayilari mevsime ve ostrus donemlerine gore degismektedir. Kiss1 noronlari norokinin B ve dinofrin gibi steroitlerin feedback kontrol mekanizmasinda onemli rolleri olan diger noropeptidlerin ekspresyonunu gerceklestirmektedir. Kisspeptin gonadotropin sekrasyonunu uyarip ovulasyonu senkronize edebildiginden fertiliteyi artiracak yeni senkronizasyon protokollerinin gelistirilmesine alternatif olabilir. ●●● The Effects of Kisspeptin System on Ewe Reproduction S U M M A R Y The Kiss 1 gene, Kiss1 reseptor and kisspeptin peptide system play an important roles in the regulation of reproductive function. Kiss1 gene products 145-amino acid precursor protein cleaved to active kisspeptin forms. The kisspeptin system have important role in the negative and positive feedback mechanism of gonadal steroids. Total kisspeptin cell number appears to differ between the arcuate and preoptic region of the hypothalamus which these cells number change with season and phases of oestrus. Kiss1 neurons express other neuropeptides such as neurokinin B and dynorphin, which may play important roles involving steroids feedback control mechanisms. The ability of kisspeptin to stimulate gonadotropin secretion and synchronization ovulation, alternatives to design new synchronization protocols aimed at improving fertility.