Inhibition of Advanced Glycation End Products Formation by Mangifera indica Leaf Extract | Zendy

Kimihisa Itoh | Zendy; Kazuya Murata | Zendy; Nao Sakaguchi | Zendy; Kohei Akai | Zendy; Tomoka Yamaji | Zendy; Kohsuke Shimizu | Zendy; Kaoru Isaki | Zendy; Tetsuya Matsukawa | Zendy; Shin’ichiro Kajiyama | Zendy; Masahiko Fumuro | Zendy; Morio Iijima | Zendy; Hideaki Matsuda | Zendy

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Inhibition of Advanced Glycation End Products Formation by Mangifera indica Leaf Extract

Author(s) -

Kimihisa Itoh,

Kazuya Murata,

Nao Sakaguchi,

Kohei Akai,

Tomoka Yamaji,

Kohsuke Shimizu,

Kaoru Isaki,

Tetsuya Matsukawa,

Shin’ichiro Kajiyama,

Masahiko Fumuro,

Morio Iijima,

Hideaki Matsuda

Publication year - 2017

Publication title -

journal of plant studies

Language(s) - English

Resource type - Journals

eISSN - 1927-047X

pISSN - 1927-0461

DOI - 10.5539/jps.v6n2p102

Subject(s) - mangifera , glycation , chemistry , mangiferin , inhibitory postsynaptic potential , botany , food science , biochemistry , biology , chromatography , receptor , neuroscience

The purpose of this study was to examine an inhibitory effect of mango lea f extracts on advanced glycation end products (AGEs) formation and to identify these active ingredients, and also to investigate a relationship between leaves maturation and the inhibitory activity. A methanolic extract of old dark green mango leaf extract (OML-ext) exhibited an inhibitory activity of AGEs formation in nonenzymatic glycation of albumin. The inhibitory activity of OML-ext was attributable to 3-C- β - D -glucosyl-2,4,4’,6-tetrahydroxybenzophenone ( 1 ), mangiferin ( 2 ) and chlorophyll. Inhibitory effect of young dark reddish brown mango leaf extract (YDL-ext) on AGEs formation was similar to that of OML-ext. The inhibitory activity of YDL-ext was attributable to 1 and 2 , in addition, a part of the the activity of YDL-ext due to anthocyanins whose content is highest in young dark reddish brown mango leaves. Considering the amounts of leaves obtained from pruning, old dark green leaves may be a reasonable natural resource for the preparation of ingredients with inhibitory activity of AGEs formation.

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