Cytokine and Chemokine Expression Profiles in HIV-1 Infected Patients with Ocular Surface Squamous Neoplasia from Botswana | Zendy

Kenneth O. Simbiri | Zendy; Hem Chandra Jha | Zendy; Richard D Dzeng | Zendy; Giacomina MassaroGiordano | Zendy; Erle S. Robertson | Zendy

Open Access

Cytokine and Chemokine Expression Profiles in HIV-1 Infected Patients with Ocular Surface Squamous Neoplasia from Botswana

Author(s) -

Kenneth O. Simbiri,

Hem Chandra Jha,

Richard D Dzeng,

Giacomina MassaroGiordano,

Erle S. Robertson

Publication year - 2012

Publication title -

cancer and clinical oncology

Language(s) - English

Resource type - Journals

eISSN - 1927-4866

pISSN - 1927-4858

DOI - 10.5539/cco.v1n2p10

Subject(s) - proinflammatory cytokine , chemokine , pathogenesis , immunology , medicine , immune system , cytokine , carcinogenesis , inflammation , cancer

Purpose: Ocular surface squamous neoplasia (OSSN) rate has increased in incidence with the HIV pandemic in Africa. Multiple factors including cellular and environmental can affect the pathogenesis of OSSN in HIV-infected patients. We will investigate anti-inflammatory cytokines, proinflammatory cytokines, and growth factor expression in sera and tissue samples of OSSN and pterygia for the potential link to the development of OSSN. Results: Antibody analysis showed significant changes in levels of pro-inflammatory cytokines, anti-inflammatory cytokines and growth factors in sera. Quantitative RT-PCR of tissues showed expression of inflammatory cytokines and chemokines associated with HIV infection and carcinogenesis. Conclusion: Our findings showed that dysregulation in expression of cytokines and growth factors in patients with multiple infections may contribute to pathogenesis of OSSN and pterygia. The data reinforces the significance of in depth analysis of immune function in HIV-1 OSSN patients with multiple viral infections that has potential for therapy and vaccine development.

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