Silibinin Loaded Solid Lipid Nanoparticles: Effect of Different Lipids and Surfactants on Physicochemical Properties of Nanoparticle

Background: Solid lipid nanoparticles are rapidly developing field of nanotechnology with several potential applications in drug delivery with spherical shape and an average diameter between 1 and 1000 nm. Due to their size and its properties, solid lipid nanoparticles as drug delivery carrier have shown promising potential. Silibinin is a flavonoid with anticancer activity also possesses diverse pharmacologic effects. Methods: Solid lipid nanoparticles of silibinin are prepared by using lipids (Dynasan 114, Glyceryl mono stearate and Compritol 888ATO) with stabilizers (Soy lecithin, Poloxamer 407 and Tween 80). The prepared formulations have been evaluated for Particle size analysis, entrapment efficiency, in-vitro drug release, scanning electron spectroscopy, Fourier transform-infrared studies, Differential scanning calorimetric, Xray diffraction and Stability study. Results: EE raised with increasing the concentration of surfactants and shows inverse relationship for particle size. The in vitro release profiles of different formulations were studied and showed that sustained release of drug from all formulations. From fitting these data to various statistical models, the Korsmeyer Peppas model was proposed as the best model to describe the statistical indices and mechanism of drug release. DSC and FTIR Shows no interaction between drug and excipients. By SEM Study its shows particles are spherical in shape. Stability studies revealed no prominent changes are seen upon storage. Conclusion: Formulation containing Compritol 888 ATO and Tween 80 (3%) showed prolonged drug release upto 12 hrs, with smaller particle size and narrow particle size distribution, as compared to other formulations with different surfactants and lipids.