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Pseudomonas aeruginosa is a bothersome pathogen on the rise and prone to developing resistance during treatment. Hospitalized patients are especially prone to its detrimental effects. Aims: To determine the prevalence and antimicrobial susceptibility pattern of Mono therapy and combination therapy of Cefepime in Pseudomonas aeruginosa isolates obtained from patients at a tertiary care hospital in Karachi, Pakistan. Methods: This study was conducted at a university-affiliated, urban teaching hospital. During a 2-year period (January 2013 to December 2015), all hospitalized patients with a positive blood culture for P. aeruginosa were eligible for this investigation, amounting to a sample size of 634, and a cross sectional study was performed. Standard microbiological methods were used to identify the clinical isolates.  The isolates were cultured on chocolate and MacConkey agar. Results:  Throughout the duration of this study, 634 isolates of P. aeruginosa were cultured. Positive cultures were then tested against the following drugs:  Cefepime, Meropenem, Amikacin and Ciprofloxacin. Cefepime was 76.2% (483) sensitive for isolates while the age and sex relationship analysis showed that isolates gathered from 0-18 year old females were 94.6% sensitive to Cefepime. Around 63.25% isolates were sensitive to the combination of Cefepime and Amikacin while the combination offering the least resistance was that of Cefepime and Ciprofloxacin (7.1%). Conclusions:  P. aeruginosa  isolates show a progressive trend of resistance to Cefepime. Cefepime when used in combination with Ciprofloxacin, potentially will be more effective than monotherapy with Cefepime.

international journal of medicine and public health

Prevalence and Antimicrobial Susceptibility Pattern of Mono therapy and combination therapy of Cefepime in Pseudomonas aeruginosa isolates of patients from a tertiary care hospital in Karachi, Pakistan