The Value of Serum Immunoglobulin Free Light Chain Assessment in Patients with Monoclonal Gammopathies and Acute Renal Failure | Zendy

Mustafa Ci̇ri̇t | Zendy; Atilla Üzüm | Zendy; Pınar Özen | Zendy; Banu A. Senturk | Zendy; Giray Bozkaya | Zendy; Bahriye Payzın | Zendy; Orçun Ural | Zendy

Open Access

The Value of Serum Immunoglobulin Free Light Chain Assessment in Patients with Monoclonal Gammopathies and Acute Renal Failure

Author(s) -

Mustafa Ci̇ri̇t,

Atilla Üzüm,

Pınar Özen,

Banu A. Senturk,

Giray Bozkaya,

Bahriye Payzın,

Orçun Ural

Publication year - 2012

Publication title -

turkish journal of hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.351

H-Index - 16

ISSN - 1308-5263

DOI - 10.5505/tjh.2012.48640

Subject(s) - medicine , serum protein electrophoresis , immunofixation , multiple myeloma , immunoglobulin light chain , monoclonal , antibody , monoclonal gammopathy of undetermined significance , immunoassay , gastroenterology , pathology , monoclonal antibody , immunology

Immunoglobulin free light chain (FLC) abnormalities are common in patients with monoclonal gammopathies and the kidneys are the most affected organs. Immunoassays that provide quantitative measurement of FLC in serum indicate monoclonal FLC production based on the presence of an abnormal FLC kappa:lambda (κ:λ) ratio. The aim of this study was to assess the utility of serum FLC measurement as a diagnostic tool for detecting plasma cell dyscrasias in comparison to standard assays, and to ascertain its sensitivity and specificity in patients with acute renal failure (ARF).

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