Hereditary thrombophilia risk factors in patients with venous thromboembolism

The annual incidence of VTD is 0.001% in children and 0.1% in adults (1,2). The incidence increases with age, reaching 1% over the age of 85 years(1,2). Of the VTD patients, two thirds have lower limb deep vein thrombosis (DVT) and one third have pulmonary embolism (PE) (2). The major complications of VTD are post-thrombotic syndrome, major bleeding due to anticoagulation, recurrence and death (1,2).