Metabolic features and regulation in cell senescence | Zendy

So Mee Kwon | Zendy; Sun Mi Hong | Zendy; YoungKyoung Lee | Zendy; Seongki Min | Zendy; Gyesoon Yoon | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Metabolic features and regulation in cell senescence

Author(s) -

So Mee Kwon,

Sun Mi Hong,

YoungKyoung Lee,

Seongki Min,

Gyesoon Yoon

Publication year - 2019

Publication title -

bmb reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.511

H-Index - 77

eISSN - 1976-670X

pISSN - 1976-6696

DOI - 10.5483/bmbrep.2019.52.1.291

Subject(s) - senescence , cellular senescence , metabolic regulation , microbiology and biotechnology , computational biology , biology , metabolism , genetics , biochemistry , phenotype , gene

Organismal aging is accompanied by a host of progressive metabolic alterations and an accumulation of senescent cells, along with functional decline and the appearance of multiple diseases. This implies that the metabolic features of cell senescence may contribute to the organism’s metabolic changes and be closely linked to age-associated diseases, especially metabolic syndromes. However, there is no clear understanding of senescent metabolic characteristics. Here, we review key metabolic features and regulators of cellular senescence, focusing on mitochondrial dysfunction and anabolic deregulation, and their link to other senescence phenotypes and aging. We further discuss the mechanistic involvement of the metabolic regulators mTOR, AMPK, and GSK3, proposing them as key metabolic switches for modulating senescence.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research