Open AccessSignal crosstalk between estrogen and peroxisome proliferator-activated receptor α on adiposity
Author(s) -
Bang-Hyun Kim,
Young Suk Won,
Dae Yong Kim,
Bora Kim,
EunYoung Kim,
Mi-Jung Yoon,
Goo Taeg Oh
Publication year - 2009
Publication title -
bmb reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.511
H-Index - 77
eISSN - 1976-670X
pISSN - 1976-6696
DOI - 10.5483/bmbrep.2009.42.2.091
Subject(s) - endocrinology , medicine , adipose tissue , peroxisome proliferator activated receptor , lipoprotein lipase , white adipose tissue , ovariectomized rat , crosstalk , peroxisome proliferator activated receptor alpha , receptor , estrogen receptor alpha , estrogen , estrogen receptor , obesity , chemistry , biology , nuclear receptor , transcription factor , biochemistry , breast cancer , physics , cancer , gene , optics
Peroxisome proliferator-activated receptor alpha and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPAR alpha-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E(2)-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E(2)-treated group, but interestingly not in PPAR alpha-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E(2)-treated mice. These novel results suggest the possibility of signaling crosstalk between PPAR alpha and E2, causing obesity in vivo.
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