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Amac: Aksiller lenf nodu metastazli invaziv duktal meme karsinomda E-cadherin, p53 tumor supressor gen, c-erbB-2 (HER2/neu) ve steroid reseptorleri (ER ve PgR) ekspresyonu arasindaki iliskiyi arastirmak amaclanmistir.Hastalar ve Yontem: Bu calismada, 30 aksiller lenf nodu metastazli ve 30 aksiller lenf nodu metastazi mevcut olmayan invaziv duktal meme karsinomlu 60 hasta immunokimyasal metodu kullanilarak E-cadherin ve c-erbB-2, ER ve PgR antikorlari degerlendirildi.Bulgular: Invaziv duktal meme karsinomlu 60 hastanin 39’unda (%65) E-cadherin ile boyanma tesbit edilmedi. Sirasiyla ER, PgR, p53, ve c-erb-B2, 60 hastanin 36’inda (%60), 60 hastanin 26’inda (%43,3), 60 hastanin 33’unde (%55), and 60 hastanin 29’unda (%48,3) pozitif boyanma goruldu. PgR ve c-erb-B2 boyanmasi lenf nodu metastazi ile iliskili idi (sirasiyla, p=0,009, p=0,001). E-cadherin proteini ile yas arasinda iliski gorulmedi. E-cadherin ile lenf nodu metastazi ve p53 arasinda iliski goruldu (sirasiyla, p

marmara üniversitesi tıp fakültesi dergisi

Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases