Pack in or go on: Topographic disorientation induced by bupropion sustained release tablet

The mechanism of effect of bupropion is unknown. The authors report a case of bupropion-associated topographic disorientation during bupropion treatment for smoking cessation. A 44-year-old female patient with a history not knowing where she is, the inability to recognize the surrounding buildings was admitted to neurology department. During her admission, her symptoms disappeared and she did not continue her medication. There was no abnormality in the investigation. It was concluded that the onset of symptoms was dose dependent. Bupropion may cause unusual neuropsychiatric behaviors. This case suggests that topographic disorientation may be the primary symptom of bupropion toxicity.