Open AccessMitochondrial Uncoupling Proteins in the Brain: Their Structure, Function and Physiological Roles [Beyindeki Mitokondriyal Eslesme Bozucu Proteinler: Yapisi, Islevi ve Fizyolojik Rolleri]
Author(s) -
Yavuz Erden,
Suat Tekin,
Sevda Kırbağ,
Süleyman Sandal
Publication year - 2014
Publication title -
medicine science | international medical journal
Language(s) - English
Resource type - Journals
ISSN - 2147-0634
DOI - 10.5455/medscience.2014.03.8216
Subject(s) - neuroprotection , biology , function (biology) , mitochondrion , neuroscience , energy metabolism , uncoupling protein , microbiology and biotechnology , biochemistry , endocrinology , brown adipose tissue , adipose tissue
Uncoupling proteins (UCPs) which belong to mitochondrial anion carrier family are important because of their special distribution to different tissues and their intrinsic physiological function at those tissues. The UCP1 found in the brown fat tissue and being the most well-known member of this family takes in charge for arranging energy metabolism and body temperature. Other members of UCPs family (UCP2, UCP4 and UCP5) demonstrate a broad spread in neural field. Neural UCPs participate in regulating neuroendocrine functions, in forming free radicals production, in conveying neuroprotection and neurotransmission in central nervous system. The aim of this compilation is to provide a better understanding of physiological roles of neural UCPs.
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