Covariates of amikacin disposition in a large pediatric oncology cohort | Zendy

Isabelle Dewandel | Zendy; Karel Allegaert | Zendy; Marleen Renard | Zendy; Annouschka Laenen | Zendy; Anne Smits | Zendy

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Covariates of amikacin disposition in a large pediatric oncology cohort

Author(s) -

Isabelle Dewandel,

Karel Allegaert,

Marleen Renard,

Annouschka Laenen,

Anne Smits

Publication year - 2020

Publication title -

international journal of clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.363

H-Index - 67

ISSN - 0946-1965

DOI - 10.5414/cp203793

Subject(s) - amikacin , medicine , therapeutic drug monitoring , dosing , cohort , covariate , pediatric oncology , pediatric cancer , pharmacokinetics , interquartile range , cohort study , pediatrics , oncology , cancer , antibiotics , statistics , biology , mathematics , microbiology and biotechnology

Amikacin pharmacokinetics (PK) in children display large variability due to maturational and disease-related covariates. The objective was to explore amikacin PK in a large pediatric oncology cohort, taking into account within-patient changes.

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