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The barks and leaves extracts of  Canarium patentinervium  Miq. (Burseraceae Kunth.) were investigated for cyclooxygenase (COX) and 5-lipoxygenase (LOX) inhibition via  in vitro  models. The corresponding antioxidative power of the plant extract was also tested via nonenzyme and enzyme  in vitro  assays. The ethanolic extract of leaves inhibited the enzymatic activity of 5-LOX, COX-1, and COX-2 with IC 50  equal to 49.66 ± 0.02  μ g/mL, 0.60 ± 0.01  μ g/mL, and 1.07 ± 0.01  μ g/mL, respectively, with selective COX-2 activity noted in ethanolic extract of barks with COX-1/COX-2 ratio of 1.22. The ethanol extract of barks confronted oxidation in the ABTS, DPPH, and FRAP assay with EC 50  values equal to 0.93 ± 0.01  μ g/mL, 2.33 ± 0.02  μ g/mL, and 67.00 ± 0.32  μ g/mL, respectively, while the ethanol extract of leaves confronted oxidation in  β -carotene bleaching assay and superoxide dismutase (SOD) assay with EC 50  value of 6.04 ± 0.02  μ g/mL and IC 50  value of 3.05 ± 0.01  μ g/mL. The ethanol extract acts as a dual inhibitor of LOX and COX enzymes with potent antioxidant capacity. The clinical significance of these data is quite clear that they support a role for  Canarium patentinervium  Miq. (Burseraceae Kunth.) as a source of lead compounds in the management of inflammatory diseases.

isrn biotechnology

The Medicinal Timber <i>Canarium patentinervium</i> Miq. (Burseraceae Kunth.) Is an Anti-Inflammatory Bioresource of Dual Inhibitors of Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX)

The Medicinal Timber Canarium patentinervium Miq. (Burseraceae Kunth.) Is an Anti-Inflammatory Bioresource of Dual Inhibitors of Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX)