Lysophosphatidic Acid Stimulates MCP-1 Secretion from C2C12 Myoblast | Zendy

Tamotsu Tsukahara | Zendy; Hisao Haniu | Zendy

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Lysophosphatidic Acid Stimulates MCP-1 Secretion from C2C12 Myoblast

Author(s) -

Tamotsu Tsukahara,

Hisao Haniu

Publication year - 2012

Publication title -

isrn inflammation

Language(s) - English

Resource type - Journals

ISSN - 2090-8695

DOI - 10.5402/2012/983420

Subject(s) - lysophosphatidic acid , c2c12 , secretion , microbiology and biotechnology , phosphatidic acid , chemistry , monocyte , chemokine , cell growth , biology , endocrinology , myocyte , receptor , biochemistry , myogenesis , immunology , phospholipid , membrane

Chemokines are regulatory proteins that play an important role in muscle cell migration and proliferation. In this study, C2C12 cells treated with lysophosphatidic acid (LPA) showed an increase in endogenous monocyte chemotactic protein-1 (MCP-1) expression and secretion. LPA is a naturally occurring bioactive lysophospholipid with hormone- and growth-factor-like activities. LPA is produced by activated platelets, cytokine-stimulated leukocytes, and possibly by other cell types. However, the LPA analog cyclic phosphatidic acid (cPA) had no effect on the expression and secretion of MCP-1. LPA, although similar in structure to cPA, had potent inducing effects on MCP-1 expression in C2C12 cells. In this study, we showed that LPA enhanced MCP-1 mRNA expression and protein secretion in a dose-dependent manner. Taken together, these results suggest that LPA enhances MCP-1 secretion in C2C12 cells and thus may play an important role in cell proliferation.

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