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A series of novel 4-amino-5-mercapto-3-[(3-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazoles ( 5a-d ) were obtained by treating  m -(aralkyl amido/imidoalkyl) benzoic acid hydrazides ( 3a-d ) with carbon disulphide in alcoholic KOH and hydrazine hydrate, respectively. These triazole derivatives were employed in the synthesis of 5-[(3′-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazolo[3,4- b ]-1,3,4-thiadiazines ( 6a-d ). The newly synthesized compounds were evaluated for their antiviral activity against two animal viruses, namely,  Japanese encephalitis virus  (JEV) strain P20778 and  herpes simplex virus-1  (HSV-1) strain 753166.

isrn organic chemistry

Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-<i>b</i>]-1,3,4-Thiadiazines as Antiviral Agents

Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents