Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents | Zendy

Vinod Kumar Pandey | Zendy; Zehra Tusi | Zendy; Sumerah Tusi | Zendy; M. N. Joshi | Zendy

Open Access

Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents

Author(s) -

Vinod Kumar Pandey,

Zehra Tusi,

Sumerah Tusi,

M. N. Joshi

Publication year - 2012

Publication title -

isrn organic chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-5157

pISSN - 2090-5149

DOI - 10.5402/2012/760517

Subject(s) - chemistry , hydrazine (antidepressant) , hydrate , benzoic acid , strain (injury) , medicinal chemistry , herpes simplex virus , virus , stereochemistry , organic chemistry , virology , biochemistry , biology , anatomy

A series of novel 4-amino-5-mercapto-3-[(3-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazoles ( 5a-d ) were obtained by treating m -(aralkyl amido/imidoalkyl) benzoic acid hydrazides ( 3a-d ) with carbon disulphide in alcoholic KOH and hydrazine hydrate, respectively. These triazole derivatives were employed in the synthesis of 5-[(3′-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazolo[3,4- b ]-1,3,4-thiadiazines ( 6a-d ). The newly synthesized compounds were evaluated for their antiviral activity against two animal viruses, namely, Japanese encephalitis virus (JEV) strain P20778 and herpes simplex virus-1 (HSV-1) strain 753166.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research