Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release | Zendy

Jadupati Malakar | Zendy; Amit Kumar Nayak | Zendy; Soumita Goswami | Zendy

Open Access

Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

Author(s) -

Jadupati Malakar,

Amit Kumar Nayak,

Soumita Goswami

Publication year - 2012

Publication title -

isrn pharmaceutics

Language(s) - English

Resource type - Journals

eISSN - 2090-6153

pISSN - 2090-6145

DOI - 10.5402/2012/730624

Subject(s) - bisoprolol , matrix (chemical analysis) , factorial experiment , response surface methodology , materials science , pharmacology , chemistry , chromatography , medicine , mathematics , heart failure , statistics

The aim of this investigation was to develop and optimize bisoprolol fumarate matrix tablets for sustained release application by response surface methodology based on 2 3 factorial design. The effects of the amounts of calcium alginate, HPMC K4M, and Carbopol 943 in bisoprolol fumarate matrix tablets on the properties of bisoprolol fumarate sustained release matrix tablets like drug release and hardness were analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. The optimized bisoprolol fumarate matrix tablets showed prolonged sustained release of bisoprolol fumarate over 6 hours. These matrix tablets followed the first-order model with anomalous (non-Fickian) diffusion mechanism.

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