Evaluation of Eye Irritation Potential of Aqueous Leaf Extract of Achyranthes aspera by In Vitro and In Vivo Method | Zendy

Gajanan Rajpal Deshmukh | Zendy; Kuntrapakam Hema Kumar | Zendy; Poojari Venkata Suresh Reddy | Zendy; Boddapati Srinivasa Rao | Zendy; Chirumamilla Venkata Satish Kumar | Zendy

Open Access

Evaluation of Eye Irritation Potential of Aqueous Leaf Extract of Achyranthes aspera by In Vitro and In Vivo Method

Author(s) -

Gajanan Rajpal Deshmukh,

Kuntrapakam Hema Kumar,

Poojari Venkata Suresh Reddy,

Boddapati Srinivasa Rao,

Chirumamilla Venkata Satish Kumar

Publication year - 2012

Publication title -

isrn toxicology

Language(s) - English

Resource type - Journals

eISSN - 2090-6196

pISSN - 2090-6188

DOI - 10.5402/2012/693489

Subject(s) - achyranthes aspera , irritation , eye irritation , in vivo , traditional medicine , in vitro , chorioallantoic membrane , aqueous extract , pharmacology , chemistry , medicine , biology , microbiology and biotechnology , pathology , biochemistry , immunology , alternative medicine

The present paper is an attempt to investigate the eye irritation potential of aqueous leaf extract of Achyranthes aspera by in vitro , Hen's Egg Chorioallantoic Membrane Test (HET-CAM) and in vivo acute eye irritation test in rabbits. The irritation score (IS) obtained after treatment of the extract on HET-CAM is 0.07 and that of in rabbits is 0.55, Which does not comes under either category 1 or 2 as per the harmonized integrated classification system. The aqueous extract of Achyranthes aspera showed no eye irritation properties both in vitro and in vivo methods when compared with negative control whereas positive controls showed eye irritation potential.

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