Open AccessConstrained Peptides as Miniature Protein Structures
Author(s) -
Hang Yin
Publication year - 2012
Publication title -
isrn biochemistry
Language(s) - English
Resource type - Journals
ISSN - 2090-7729
DOI - 10.5402/2012/692190
Subject(s) - peptidomimetic , covalent bond , chemistry , forcing (mathematics) , non covalent interactions , protein engineering , peptide , nanotechnology , computational biology , biophysics , biochemistry , biology , materials science , physics , molecule , organic chemistry , hydrogen bond , atmospheric sciences , enzyme
This paper discusses the recent developments of protein engineering using both covalent and noncovalent bonds to constrain peptides, forcing them into designed protein secondary structures. These constrained peptides subsequently can be used as peptidomimetics for biological functions such as regulations of protein-protein interactions.
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