Improvement of Water Solubility of Josamycin by Inclusion Complex with -Cyclodextrin | Zendy

J. El Harti | Zendy; Yahia Cherrah | Zendy; Abdelaziz Bouklouze | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Improvement of Water Solubility of Josamycin by Inclusion Complex with -Cyclodextrin

Author(s) -

J. El Harti,

Yahia Cherrah,

Abdelaziz Bouklouze

Publication year - 2012

Publication title -

isrn analytical chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-732X

pISSN - 2090-7311

DOI - 10.5402/2012/673564

Subject(s) - solubility , josamycin , chemistry , fourier transform infrared spectroscopy , stability constants of complexes , cyclodextrin , aqueous solution , nuclear chemistry , chromatography , propionate , inclusion compound , organic chemistry , chemical engineering , biochemistry , erythromycin , engineering , antibiotics

Josamycin propionate (JMP) is an antibiotic belonging to the family of macrolide. According to the Biopharmaceutical Classification System (BCS), this compound can be classed in class II, low solubility and high permeability. In order to increase its apparent water solubility, inclusion complexation between Josamycin propionate and γ-cyclodextrin (γ-CD) was studied. UV spectrophotometric method was employed to investigate the phase-solubility profile and the stability constant of the complexation in aqueous medium. Solid state of the binary system prepared by coevaporation (in 50%-50% ethanol/water) has been characterized using powder X-ray diffraction (XRD) and Fourier transformation-infrared spectrometry (FTIR). These techniques indicate that JMP forms an association complex with γ-CD. The shift in the nuclear magnetic resonance spectroscopy (1H NMR) confirms the existence of the inclusion complex. Also the results obtained showed an enhancement of the solubility in water of Josamycin propionate.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research