Itraconazole Niosomes Drug Delivery System and Its Antimycotic Activity against Candida albicans | Zendy

Vijay D. Wagh | Zendy; Onkar J. Deshmukh | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Itraconazole Niosomes Drug Delivery System and Its Antimycotic Activity against Candida albicans

Author(s) -

Vijay D. Wagh,

Onkar J. Deshmukh

Publication year - 2012

Publication title -

isrn pharmaceutics

Language(s) - English

Resource type - Journals

eISSN - 2090-6153

pISSN - 2090-6145

DOI - 10.5402/2012/653465

Subject(s) - niosome , itraconazole , candida albicans , permeation , pulmonary surfactant , drug , factorial experiment , chemistry , pharmacology , drug delivery , vesicle , chromatography , medicine , microbiology and biotechnology , antifungal , dermatology , biochemistry , biology , membrane , mathematics , organic chemistry , statistics

Niosomes have potential applications in topical drug delivery system. The objective of the study was to formulate and evaluate the niosome of Itraconazole. Surfactant : cholesterol ratio and quantity of ethanol used were studied by applying factorial design. Formulated niosomes were evaluated for vesicle size, entrapment efficiency, drug release, skin permeation, and antimycotic activity. Vesicle size, entrapment efficiency, and drug release were markedly dependent on surfactant : cholesterol ratio and quantity of ethanol used. Permeation of the drug through the skin was affected by cholesterol content in formulation. Itraconazole niosome were having larger zone of inhibition than marketed formulation when activity was checked against C. albicans . Niosomes may be a promising carrier for topical delivery of Itraconazole especially due to their simple production.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research