Co-localization of the PDGF β-Receptor and Actin during PDGF Stimulation in Mouse Fibroblasts | Zendy

Maarten J. A. Moes | Zendy; Yeping Zhou | Zendy; Johannes Boonstra | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Co-localization of the PDGF β-Receptor and Actin during PDGF Stimulation in Mouse Fibroblasts

Author(s) -

Maarten J. A. Moes,

Yeping Zhou,

Johannes Boonstra

Publication year - 2012

Publication title -

isrn cell biology

Language(s) - English

Resource type - Journals

eISSN - 2090-7389

pISSN - 2090-7370

DOI - 10.5402/2012/568104

Subject(s) - platelet derived growth factor receptor , microbiology and biotechnology , receptor , internalization , pinocytosis , platelet derived growth factor , actin , biology , chemistry , endocytosis , growth factor , biochemistry

The subcellular localization of the PDGF β-receptor was investigated in relation with PDGF-induced actin and membrane dynamics in mouse C3H10T1/2 fibroblasts. Serum-starved cells exhibit a nonhomogenous distribution of PDGF β-receptors. However, the observed pattern does not resemble the localization of PDGF-induced actin structures. Interestingly, the PDGF β-receptor showed a changed subcellular distribution in relation to the formation of PDGF-BB-induced actin structures. Upon PDGF exposure, PDGF β-receptors were found to accumulate in dorsal circular ruffles. The presence of both macropinosomes and clathrin in the induced circular ruffles suggests that the accumulation of PDGF β-receptors in circular ruffles results in the efficient internalization of PDGF β-receptors.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research