New Way of Direct Nitrogen Atom Phenylation in Quinoline Derivatives
Author(s) -
Н. Е. Щепина,
В. В. Аврорин,
Г. А. Бадун,
Scott B. Lewis,
С. Н. Шуров
Publication year - 2012
Publication title -
isrn organic chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-5157
pISSN - 2090-5149
DOI - 10.5402/2012/526867
Subject(s) - nitrogen atom , quinoline , tritium , chemistry , nitrogen , salt (chemistry) , atom (system on chip) , ion , radiochemistry , medicinal chemistry , inorganic chemistry , organic chemistry , ring (chemistry) , computer science , physics , nuclear physics , embedded system
Comparison of ion-molecular reactions of free-phenyl cations generated by tritium β -decay with 2-methyl- and 2-phenylquinolines has been investigated. The reaction of direct nitrogen atom phenylation with the help of nucleogenic phenyl cations has been fulfilled for the first time and a new one-step synthesis of tritium-labeled N -phenyl-2-phenylquinolinium salt—lipophilic radioactive biological marker has been elaborated.
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