N-tert-Butoxycarbonylation of Structurally Diverse Amines and Sulfamides under Water-Mediated Catalyst-Free Conditions | Zendy

Zinelaabine Cheraiet | Zendy; Souad Ouarna | Zendy; Sihem Hessainia | Zendy; Malika Berredjem | Zendy; NourEddine Aouf | Zendy

Open Access

N-tert-Butoxycarbonylation of Structurally Diverse Amines and Sulfamides under Water-Mediated Catalyst-Free Conditions

Author(s) -

Zinelaabine Cheraiet,

Souad Ouarna,

Sihem Hessainia,

Malika Berredjem,

NourEddine Aouf

Publication year - 2012

Publication title -

isrn organic chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-5157

pISSN - 2090-5149

DOI - 10.5402/2012/404235

Subject(s) - chemistry , moiety , amine gas treating , catalysis , isocyanate , urea , acetone , organic chemistry , combinatorial chemistry , polymer chemistry , polyurethane

A simple, efficient, and eco-friendly protocol for the N -Boc protection of the amine moiety in a variety of compounds with di- tert -butyl dicarbonate under water-acetone catalyst-free conditions is described. The corresponding monocarbamate is obtained in excellent yields on short reaction times. No competitive side reactions such as isocyanate urea and O-Boc were observed. This method represents a reasonable alternative to the previous reported protection procedures.

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