Molecular Mechanisms of Cytotoxicity and Apoptosis Induced by Inorganic Fluoride | Zendy

Natalia I. Agalakova | Zendy; Г. П. Гусев | Zendy

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Molecular Mechanisms of Cytotoxicity and Apoptosis Induced by Inorganic Fluoride

Author(s) -

Natalia I. Agalakova,

Г. П. Гусев

Publication year - 2012

Publication title -

isrn cell biology

Language(s) - English

Resource type - Journals

eISSN - 2090-7389

pISSN - 2090-7370

DOI - 10.5402/2012/403835

Subject(s) - fluoride , apoptosis , signal transduction , oxidative stress , microbiology and biotechnology , chemistry , cytochrome c , mitochondrion , reactive oxygen species , caspase , kinase , biochemistry , programmed cell death , biology , inorganic chemistry

Fluoride (F) is ubiquitous natural substance and widespread industrial pollutant. Although low fluoride concentrations are beneficial for normal tooth and bone development, acute or chronic exposure to high fluoride doses results in adverse health effects. The molecular mechanisms underlying fluoride toxicity are different by nature. Fluoride is able to stimulate G-proteins with subsequent activation of downstream signal transduction pathways such as PKA-, PKC-, PI3-kinase-, Ca2

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