Open AccessDocking Applied to the Study of Inhibitors of c-Met Kinase
Author(s) -
Luciana Gavernet,
Pablo H. Palestro,
Luis E. BrunoBlanch
Publication year - 2011
Publication title -
isrn physical chemistry
Language(s) - English
Resource type - Journals
ISSN - 2090-7761
DOI - 10.5402/2012/391897
Subject(s) - docking (animal) , quinoxaline , kinase , chemistry , computational biology , combinatorial chemistry , stereochemistry , pharmacology , cancer research , biochemistry , biology , medicine , organic chemistry , nursing
Quinoxaline derivatives were studied as inhibitors of c-Met kinase, a receptor associated with high tumor grade and poor prognosis in a number of human cancers. In this paper we used docking methodologies to predict the binding conformation of a set of quinoxalines and to explain the differences of biological activities previously reported.
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