Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin | Zendy

Yukio Murakami | Zendy; Mamoru Machino | Zendy; Seiichiro Fujisawa | Zendy

Open Access

Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin

Author(s) -

Yukio Murakami,

Mamoru Machino,

Seiichiro Fujisawa

Publication year - 2012

Publication title -

isrn dentistry

Language(s) - English

Resource type - Journals

eISSN - 2090-438X

pISSN - 2090-4371

DOI - 10.5402/2012/350859

Subject(s) - porphyromonas gingivalis , fimbria , proinflammatory cytokine , periodontitis , lipopolysaccharide , melatonin , treponema denticola , cyclooxygenase , chemistry , microbiology and biotechnology , saliva , immunology , inflammation , medicine , biology , enzyme , biochemistry , virulence , gene

Porphyromonas gingivalis (Pg) fimbriae, in addition to lipopolysaccharide, are involved in the pathogenesis of periodontal disease. At the same time, bioactive compounds such as fibronectin (FN) and melatonin in saliva and gingival crevicular fluid have been reported to exert a preventive effect against periodontitis. Here, we review current knowledge regarding the potent inhibitory effects of FN and melatonin against Pg fimbria-induced induction of proinflammatory cytokines, cyclooxygenase-2 (COX-2) expression, and NF-kappa B activation in mouse macrophages and discuss their possible clinical application for prevention of periodontal diseases induced by oral bacteria.

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