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Ambient sulphur dioxide (SO 2 ) concentrations may affect the number of female emergency department (ED) visits for migraine. ED visits diagnosed as migraine among females in two cities in Canada, Toronto ( N  = 704) and Ottawa ( N  = 3, 358), were analyzed. In the study case-crossover design was used. Conditional logistic regression was realized to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) relative to an increase in an interquartile range (IQR, in Toronto IQR = 2.9 ppb, in Ottawa IQR = 3.9 ppb) of sulphur dioxide. In the constructed conditional logistic regression models, temperature and relative humidity were adjusted in the form of natural splines. In Toronto positive and statistically significant associations of sulphur dioxide with migraine ED visits were obtained: all ages, OR = 1.04 (95% CI: 1.00, 1.08); age group [15, 50], OR = 1.05 (95% CI: 1.01, 1.09). In Ottawa positive correlations were observed: all ages, OR = 1.05 (95% CI: 0.97, 1.13); age group [15, 50], OR = 1.06 (95% CI: 0.97, 1.15). The results suggest that female migraine may be affected by ambient sulphur dioxide.

Ambient Sulphur Dioxide and Female ED Visits for Migraine