Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies | Zendy

Yen-Chen Chen | Zendy; Yun-Ching Chen | Zendy; WenDar Lin | Zendy; ChungDer Hsiao | Zendy; HungWen Chiu | Zendy; Jan-Ming Ho | Zendy

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Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies

Author(s) -

Yen-Chen Chen,

Yun-Ching Chen,

WenDar Lin,

ChungDer Hsiao,

HungWen Chiu,

Jan-Ming Ho

Publication year - 2011

Publication title -

isrn bioinformatics

Language(s) - English

Resource type - Journals

eISSN - 2090-7346

pISSN - 2090-7338

DOI - 10.5402/2012/139842

Subject(s) - annotation , pipeline (software) , computer science , information retrieval , preprocessor , gene ontology , ontology , interface (matter) , world wide web , biology , gene , gene expression , artificial intelligence , programming language , biochemistry , philosophy , epistemology , bubble , maximum bubble pressure method , parallel computing

In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information.

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