Activity of Cuban Plants Extracts againstLeishmania amazonensis | Zendy

Marley García | Zendy; Lianet Monzote | Zendy; Ramón Scull | Zendy; Pedro José Canto Herrera | Zendy

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Activity of Cuban Plants Extracts againstLeishmania amazonensis

Author(s) -

Marley García,

Lianet Monzote,

Ramón Scull,

Pedro José Canto Herrera

Publication year - 2012

Publication title -

isrn pharmacology

Language(s) - English

Resource type - Journals

eISSN - 2090-5173

pISSN - 2090-5165

DOI - 10.5402/2012/104540

Subject(s) - leishmaniasis , amastigote , leishmania , biology , bioassay , traditional medicine , medicine , immunology , parasite hosting , ecology , world wide web , computer science

Natural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a major health problem worldwide that affects millions of people especially in the developing nations. There is no immunoprophylaxis (vaccination) available for Leishmania infections, and conventional treatments are unsatisfactory; therefore, antileishmanial drugs are urgently needed. In this work, 48 alcoholic extracts from 46 Cuban plants were evaluated by an in vitro bioassay against Leishmania amazonensis. Furthermore, their toxicity was assayed against murine macrophage. The three most potent extracts against the amastigote stage of Leishmania amazonensis were from Hura crepitans, Bambusa vulgaris, and Simarouba glauca.

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