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Background.  Clinical experiences  in vitro  and clinical studies have demonstrated the curative potency and safety of Citrus/Cydonia compositum in seasonal allergic rhinitis treatment.  Objectives.  To compare the efficacy and safety of two routes of administration (nasal spray versus subcutaneous injections).  Methodology: Design.  a national, randomised, comparative clinical trial with two parallel groups.  Participants.  23 patients fulfilled the study requirements.  Intervention.  after a one- or two-week wash-out period, 23 patients were randomized, to a 6-week treatment period.  Outcomes.  immunological and symptom severity changes and safety. Immunologic outcome assessments were blinded to group assignment. 23 patients were randomized and from 22/23 patients (11 in each group) blood samples were analyzed before and after treatment.  Conclusion.  Both routes of administration demonstrate immunological and clinical effects, with larger inflammatory and innate immunological effects of the nasal spray route and larger allergen-specific clinical effects of the subcutaneous route, and are safe.

isrn allergy

Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety