Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability | Zendy

Diane M. Citron | Zendy; Yumi A. Warren | Zendy; Kerin L. Tyrrell | Zendy; Ellie J. C. Goldstein | Zendy

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Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens: Effect of Test Method Variability

Author(s) -

Diane M. Citron,

Yumi A. Warren,

Kerin L. Tyrrell,

Ellie J. C. Goldstein

Publication year - 2011

Publication title -

isrn microbiology

Language(s) - English

Resource type - Journals

eISSN - 2090-7486

pISSN - 2090-7478

DOI - 10.5402/2011/787290

Subject(s) - cephalosporin , microbiology and biotechnology , gram , minimum inhibitory concentration , staphylococcus aureus , streptococcus pneumoniae , moraxella catarrhalis , biology , bacteria , antibiotics , genetics

Ceftaroline is a new cephalosporin with bactericidal activity against methicillin-resistant S. aureus (MRSA) as well as gram-negative pathogens. Variations of in vitro test conditions were found to affect ceftaroline activity, with 5% NaCl inhibiting growth and/or reducing the minimum inhibitory concentrations (MICs) for E. coli, K. pneumoniae, M. catarrhalis, H. influenzae, and streptococci, while an inoculum of 10 6 CFU/mL raised MICs of some E. coli, K. pneumoniae, and M. catarrhalis strains.

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