Open AccessSynthesis, Characterization, Thermal Properties, and Antimicrobial Activities of 5-(Diethylamino)-2-(5-nitro-1H-benzimidazol-2-yl)phenol and Its Transition Metal Complexes
Author(s) -
Vikas S. Padalkar,
Vikas Patil,
Vinod D. Gupta,
Kiran R. Phatangare,
Prashant G. Umape,
Nagaiyan Sekar
Publication year - 2011
Publication title -
isrn organic chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-5157
pISSN - 2090-5149
DOI - 10.5402/2011/738361
Subject(s) - phenol , chemistry , nitro , transition metal , antimicrobial , nuclear chemistry , ligand (biochemistry) , metal , minimum inhibitory concentration , antibacterial activity , proton nmr , thermal analysis , elemental analysis , coordination complex , medicinal chemistry , stereochemistry , inorganic chemistry , organic chemistry , bacteria , biochemistry , thermal , alkyl , receptor , genetics , physics , biology , meteorology , catalysis
Synthesis and antimicrobial activities of new metal [Co(II), Cu(II), Ni(II), and Fe(II)] complexes from 5-(diethylamino)-2-(5-nitro-1 H -benzimidazol-2-yl)phenol are described. The newly synthesized ligands were characterized by IR, 1 H NMR, and LC-MS analysis, and metal-ligand complex formations were confirmed by using atomic absorption spectroscopy and elemental analysis. All complexes show significant in vitro antibacterial activities against E. coli and S. aureus strains and in vitro antifungal activity against C. albicans and A. niger strains by using serial dilution method. The antibacterial activities were expressed as the minimum inhibitory concentration (MIC) in μ g/mL. Thermal properties and electrochemical behavior of novel transition metal complexes have been studied.
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