Open AccessEnhancement or Suppression of ACE Inhibitory Activity by a Mixture of Tea and Foods for Specified Health Uses (FOSHU) That Are Marketed as “Support for Normal Blood Pressure”
Author(s) -
Isao Murakami,
Hiroyuki Hosono,
Shigeto Suzuki,
Junichi Kurihara,
Fumio Itagaki,
Machiko Watanabe
Publication year - 2011
Publication title -
isrn pharmaceutics
Language(s) - English
Resource type - Journals
eISSN - 2090-6153
pISSN - 2090-6145
DOI - 10.5402/2011/712196
Subject(s) - polyphenol , inhibitory postsynaptic potential , chemistry , pharmacology , blood pressure , whey protein , food science , lower blood pressure , peptide , oral administration , ic50 , antioxidant , biochemistry , endocrinology , medicine , in vitro
The ACE inhibitory activities of mixtures of FOSHUs ( Healthya, Goma-Mugicha, Lapis Support and Ameal ) were examined in order to identify any antihypertensive interactions. Among combinations of Healthya with other samples that contain active peptides, only that with Ameal was found to have no inhibitory activity. Enhanced activity was observed in 2 other mixtures. The activity of a mixture of tea polyphenols and the whey component extracted from an Ameal solution was significantly decreased, thus demonstrating that whey protein lowered the ACE inhibitory activity of Healthya . Although oral administration of tea polyphenols alone significantly decreased SBP in SHR at 2 and 4 hr, combined administration with Ameal failed to decrease SBP at the same time points. In conclusion, the simultaneous intake of tea and FOSHUs that contain active peptides might affect daily self-antihypertensive management via enhancement or suppression of ACE inhibitory activity.
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