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The ACE inhibitory activities of mixtures of FOSHUs ( Healthya, Goma-Mugicha, Lapis Support  and  Ameal ) were examined in order to identify any antihypertensive interactions. Among combinations of  Healthya  with other samples that contain active peptides, only that with  Ameal  was found to have no inhibitory activity. Enhanced activity was observed in 2 other mixtures. The activity of a mixture of tea polyphenols and the whey component extracted from an  Ameal  solution was significantly decreased, thus demonstrating that whey protein lowered the ACE inhibitory activity of  Healthya . Although oral administration of tea polyphenols alone significantly decreased SBP in SHR at 2 and 4 hr, combined administration with  Ameal  failed to decrease SBP at the same time points. In conclusion, the simultaneous intake of tea and FOSHUs that contain active peptides might affect daily self-antihypertensive management via enhancement or suppression of ACE inhibitory activity.

isrn pharmaceutics

Enhancement or Suppression of ACE Inhibitory Activity by a Mixture of Tea and Foods for Specified Health Uses (FOSHU) That Are Marketed as “Support for Normal Blood Pressure”