Epithelial Ovarian Cancer and the Occurrence of Skin Cancer in The Netherlands: Histological Type Connotations

Background . Patients with epithelial ovarian cancer have a high risk of (non-)melanoma skin cancer. The association between histological variants of primary ovarian cancer and skin cancer is poorly documented. Objectives . To further evaluate the risk of skin cancer based on the histology of the epithelial ovarian cancer. Methods . A cross-sectional study within a large population-based dataset. Results . Skin cancer was found in 2.7% (95% CI: 2.3–3.1) of the 5366 individuals forming our dataset. The odds ratio (OR) for endometrioid cancer in the ovary to skin cancer in the under 50 age group was 8.9 (95% CI: 3.2–25.0). The OR decreased in older patients to 1.2. Conclusions . Patients with epithelial ovarian malignancies show an increased risk of skin cancer. A significantly increased risk (4.3%) for endometrioid ovarian cancer was found in the group aged under 50.