Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils | Zendy

Tomasz Pospieszny | Zendy; Marcin Szymankiewicz | Zendy; Elżbieta Wyrzykiewicz | Zendy

Open Access

Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils

Author(s) -

Tomasz Pospieszny,

Marcin Szymankiewicz,

Elżbieta Wyrzykiewicz

Publication year - 2011

Publication title -

isrn organic chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-5157

pISSN - 2090-5149

DOI - 10.5402/2011/610521

Subject(s) - morpholino , in silico , pyrimidine , thio , chemistry , stereochemistry , combinatorial chemistry , computational biology , biology , biochemistry , zebrafish , gene

Six new 2- o -( m - and p -)chlorobenzylthio-6-methyl-5-piperidino-(or morpholino-) methyluracils have been prepared. The structures of these compounds were confirmed by spectroscopic (FT-IR, UV-Vis, 1 H NMR, 13 C NMR, and HMBC) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of prediction of activity spectra for substances (PASS).

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