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Objective . This study examines the effects of iron ions Fe 3+  on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an  in vitro  model of iron overload in end-stage renal disease (ESRD).  Material and Methods . Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method.  Results . At the highest used concentration of iron ions Fe 3+  (100  μ M), free radicals production by peritoneal phagocytes was reduced by 90% compared to control.  Conclusions . Iron overload may increase the risk of infectious complications in ESRD patients.

Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro