Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro | Zendy

Kamil Gotfryd | Zendy; Aleksandra Jurek | Zendy; Piotr Kubit | Zendy; Andrzej Klein | Zendy; B Turyna | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro

Author(s) -

Kamil Gotfryd,

Aleksandra Jurek,

Piotr Kubit,

Andrzej Klein,

B Turyna

Publication year - 2011

Publication title -

isrn urology

Language(s) - English

Resource type - Journals

eISSN - 2090-5815

pISSN - 2090-5807

DOI - 10.5402/2011/605436

Subject(s) - respiratory burst , peritoneal dialysis , continuous ambulatory peritoneal dialysis , respiratory system , in vitro , chemiluminescence , medicine , superoxide , chemistry , end stage renal disease , immunology , biochemistry , disease , chromatography , enzyme

Objective . This study examines the effects of iron ions Fe 3+ on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD). Material and Methods . Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method. Results . At the highest used concentration of iron ions Fe 3+ (100 μ M), free radicals production by peritoneal phagocytes was reduced by 90% compared to control. Conclusions . Iron overload may increase the risk of infectious complications in ESRD patients.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research