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Hypericum perforatum  is known to have diverse medicinal uses for centuries. The antidepressant activity of  Hypericum perforatum  is widely accepted and proved in both animal and clinical studies. Present study was undertaken to investigate the effect of  Hypericum perforatum  in a battery of animal models for metabolic disorder.  Hypericum  is tested for hypolipidemic activity in normal rats, antiobesity activity in high-fat-diet induced obese rats, and fructose-fed rats.  Hypericum  was orally administered as suspension in 0.3% carboxymethyl cellulose at the doses of 100 and 200 mg/kg body weight for 15 consecutive days.  Hypericum  significantly lowered total cholesterol and low-density cholesterol in normal rats.  Hypericum  significantly inhibited weight gain in high-fat-fed rats. In fructose-fed rats,  Hypericum  normalised the dyslipidemia induced by fructose feeding and improved the insulin sensitivity. Taken together,  Hypericum  could be the antidepressant therapy of choice for patients suffering from comorbid diabetes and obesity.

Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats